Bandera Veterinary Clinic, p.c.

MDR

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MDR-1 Multi Drug Resistent Gene


       A recent finding in canine medicine is the ability to test for the MUTANT GENE- MDR-1. Long known to be related to the ivermectin sensitivity of Collies and other herding breeds. Often refereed to as "white footed dogs". It is especially prevalent in Australian Shepherds, Collies, Shelties and their crosses. It has been found in up to 5% of mixed breed dogs with many not showing any chararcteristics of the commonly affected breeds.
Ivermectin was the first commonly known drug involved which is found in many Heartworm preventatives and livestock de-wormers. At normal heartworm prevention doses these drugs are very safe. It is when accidental overdose occurs, or when the drugs need to be used to treat other conditions at higher doses that the defective gene can be deadly.  Other drugs that are involved are other de-worming products, tranqulizers, pain meds, chemo therapy agents and maybe most importantly due to its availability in homes-IMODIUM for diarrhea. 
We have started testing dogs in our practice and will update this page as data is compiled.
Please contact us if you would like your dog to have this simple blood test or need more information.